XL 999

SKU: orb1301767

Description

Tyrosine kinase-IN-1 is a potent multi-target inhibitor, demonstrating low nanomolar IC50 values against KDR (4 nM), Flt-1 (20 nM), FGFR1 (4 nM), and PDGFRα (2 nM). This compound is a valuable research tool for studying angiogenesis and tumor cell proliferation in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 705946-27-6
• MW: 445.53
• Purity: 99.55% (May vary between batches)
• Formula: C₂₆H₂₈FN₅O
• SMILES: CCN1CCC(CC1)Nc1ccc2NC(=O)\C(=C(/c3ncc(C)[nH]3)c3cccc(F)c3)c2c1
• Target: VEGFR,PDGFR,FGFR,FLT
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (5.61 mM);DMSO:62.5 mg/mL (140.28 mM)

Bioactivity

• Target IC50:
  PDGFRα:4 nM |KDR:20 nM |FLK1:4 nM |FGFR1:2 nM
• In Vivo:
  Tyrosine kinase-IN-1 demonstrates a reasonable pharmacokinetic profile [AUC(0–∞)=1.9, t1/2=4.6 h] and possesses favorable oral bioavailability (F=63%) in rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Fibroblast growth factor receptor, FGFR, FGFR1, FLT1, KDR, inhibit, Platelet-derived growth factor receptor, Tyrosine kinaseIN1, Tyrosine kinase-IN-1, Tyrosine kinase IN 1, Vascular endothelial growth factor receptor, VEGFR, PDGFR, PDGFRα

Compound Identifiers

PubChem CID

10433653