XL-3156

SKU: orb3136386

Description

XL-3156 is a potent, selective, and cross-species inhibitor of cGAS. XL-3156 simultaneously occupies allosteric and orthosteric sites, stabilizing the closed conformation of the activation loop to inhibit the interaction and phase separation of cGAS with DNA. XL-3156 is applicable in innate immune signaling research and is used to investigate cGAS–STING pathway regulation, DNA sensing mechanisms, and phase separation-dependent activation processes in autoimmune and inflammatory disease models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 3117797-30-2
• MW: 517.54
• Purity: 99.16% (May vary between batches)
• Formula: C₂₈H₂₃N₉O₂
• SMILES: OC1=C(C(C2=CC=CC=N2)C3=C(O)N(C4=NC5=C(C=CC=C5)N4)N=C3C)C(C)=NN1C6=NC7=CC=CC=C7N6
• Target: cGAS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

cGAS