Xl-281

SKU: orb1980190

Description

Xl-281 (BMS-908662) is a selective BRAF kinase inhibitor used in cancer research. It demonstrates anti-proliferative activity in vitro and suppresses tumor growth in vivo, making it a tool for studying malignancies like melanoma and colorectal cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 870603-16-0
• MW: 462.89
• Purity: 99.12% (May vary between batches)
• Formula: C₂₄H₁₉ClN₄O₄
• SMILES: O=C(OC)NC1=NC=2C=CC(=CC2N1)C3(O)C=4C=CC=CC4C(=O)N3C5=CC(Cl)=CC=C5C
• Target: Raf

Bioactivity

• Target IC50:
  B-Raf:4.5 nM|C-Raf:2.6 nM|B-Raf (V600E):6 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B-Raf, BMS-908662

Compound Identifiers

PubChem CID

56931136