XJTU-L453

SKU: orb2665241

Description

XJTU-L453 is a potent and selective PI3Kα inhibitor (IC50 = 0.4 nM) that suppresses proliferation in breast cancer cell lines like T47D and MCF7. It induces cell cycle arrest and apoptosis by disrupting the PI3K pathway and shows significant antitumor efficacy in MCF7 xenograft mouse models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3008290-92-1
• MW: 390.44
• Formula: C₂₂H₂₂N₄O₃
• SMILES: O([C@H](C(N)=O)C)C=1C=C2C(C=3C(CO2)=CC=C(C3)C=4C=C(NCC)N=CN4)=CC1
• Target: PI3K,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172408119