Ximelagatran

SKU: orb1307599

Description

Ximelagatran

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 192939-46-1
• MW: 473.57
• Purity: 98.09% (May vary between batches)
• Formula: C₂₄H₃₅N₅O₅
• SMILES: CCOC(=O)CN[C@H](C1CCCCC1)C(=O)N1CC[C@H]1C(=O)NCc1ccc(cc1)C(\N)=N\O
• Target: Thrombin
• Solubility: DMSO:55 mg/mL (116.14 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.22 mM)

Bioactivity

• In Vitro:
  Ximelagatran, an orally administered direct thrombin inhibitor, is currently being developed for both the prophylaxis and treatment of thromboembolism. Once ingested, it is rapidly absorbed and converted into its active metabolite, Melagatran, which acts as a reversible, active-site inhibitor targeting both free and clot-bound thrombin, showcasing stable and reproducible pharmacokinetic properties. Initial research indicates Ximelagatran's promising efficacy and safety profile in preventing venous thromboembolism following total knee or hip replacement surgeries.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, H 376/95, H 37695, H 376-95, H37695, H-37695, EXANTA, inhibit, Thrombin, Ximelagatran

Compound Identifiers

PubChem CID

9574101