XEN445

SKU: orb1305899

Description

XEN445 is a potent and selective endothelial lipase inhibitor with an IC50 of 0.237 µM. It demonstrates favorable pharmacokinetic and ADME profiles, making it a useful chemical probe for researching lipid metabolism and cardiovascular diseases in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1515856-92-4
• MW: 366.33
• Purity: 99.75% (May vary between batches)
• Formula: C₁₈H₁₇F₃N₂O₃
• SMILES: OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ccccn1)C(F)(F)F
• Target: Lipase,Others
• Solubility: Ethanol:36.6 mg/mL (99.91 mM);DMSO:60 mg/mL (163.79 mM)

Bioactivity

• Target IC50:
  Endothelial lipase:0.237 μM
• In Vitro:
  XEN445 exhibits good specificity over LPL and HL, and great inhibition activity against EL.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, endothelial lipase, XEN 445, XEN445, XEN-445

Compound Identifiers

PubChem CID

72736173