XD14

SKU: orb1306810

Description

XD14 is a potent small molecule BET bromodomain inhibitor, exhibiting nanomolar binding affinity for BRD2, BRD3, and BRD4 isoforms. This compound is a valuable research tool for investigating BET protein function in epigenetic regulation, cancer biology, and inflammatory diseases in both cellular and animal models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1370888-71-3
• MW: 421.51
• Purity: 98.40% (May vary between batches)
• Formula: C₂₀H₂₇N₃O₅S
• SMILES: CCN(CC)S(=O)(=O)c1ccc(O)c(NC(=O)c2[nH]c(C)c(C(C)=O)c2CC)c1
• Target: Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.37 mM);DMSO:4.22 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  BRD3(1):380 nM (Kd)|BRD4(1):160 nM (Kd)|BRD2(1):170 nM (Kd)|BRD2(2):830 nM (Kd)|BRD4(2):850 nM (Kd)|BRD3(2):490 nM (Kd)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BET bromodomain, Inhibitor, inhibit, Epigenetic Reader Domain, EpigeneticReaderDomain, XD 14, XD14, XD-14

Compound Identifiers

PubChem CID

52670832