XAN-5

SKU: orb3210030

Description

XAN-5 is a mitochondrial DNA G-quadruplex (mtG4) ligand with a Kd value of 3.8 μM. It selectively binds to and stabilizes mtG4 structures, disrupting mitochondrial gene transcription and DNA replication. This compound induces mitochondrial dysfunction, leads to excessive production of reactive oxygen species (ROS), causes G0 phase arrest, and triggers caspase-dependent apoptosis. XAN-5 inhibits autophagy and induces immunogenic cell death. In mouse liver cancer models, XAN-5 inhibits tumor growth and enhances tumor-infiltrating CD4+ and CD8+ T cells. Additionally, XAN-5 targets two tumor resistance mechanisms and is applicable in hepatic cancer research.

Key Properties

• CAS Number: 3062796-70-4
• MW: 570.05
• Formula: C₂₉H₂₈ClNO₇S
• SMILES: O=C(O)C=1C=CC=CC1C=2C=3C=CC(=CC3[O+]=C4C(=CC=5SC=CC5)CCCC42)N(CC)CC.O=Cl(=O)(=O)[O-]
• Target: ROS,ATG,Apoptosis,Caspase,DNA/RNA Synthesis,Autophagy,Bcl-2 Family,Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,ATG,Apoptosis,Caspase,DNA/RNA Synthesis,Autophagy,Bcl-2 Family,Mitochondrial Metabolism