WZB117

SKU: orb1300139

Description

WZB117 is a potent GLUT1 inhibitor with an IC50 of approximately 10 µM, effectively suppressing the proliferation of cancer cell lines such as A549 and MCF7. It serves as a valuable research tool for studying glucose metabolism in oncology, with applications in both in vitro and in vivo models of tumor growth and energy deprivation.

Research Area

Cell Biology

Key Properties

• CAS Number: 1223397-11-2
• MW: 368.3
• Purity: >98%
• Formula: C₂₀H₁₃FO₆
• SMILES: Oc1cccc(c1)C(=O)Oc1cccc(F)c1OC(=O)c1cccc(O)c1
• Target: Glucose transporter
• Solubility: Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml)

Bioactivity

• Target IC50:
  GLUT1:10μM
• In Vivo:
  WZB117 inject 10 mg/kg daily intraperitoneal into nude mice, which were grafted human A549 lung cancer, show 70% reduction in tumor volume.
• In Vitro:
  WZB117 treats Cancer cell resulting in decreases in levels of Glut1 protein, intracellular ATP, and glycolytic enzymes. And WZB117 inhibits glucose transport in human red blood cells. The declines in cyclin E2 as well as phosphorylated retinoblastoma and increases in ATP-sensing enzyme AMP-activated protein kinase (AMPK), lead to the cell-cycle arrest, senescence, and necrosis.
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• Cell Research:
  Human non–small cell lung cancer (NSCLC) cell lines H1299 and A549 are treated with compound WZB117（10 μM） for 24 or 48 hours.
• Animal Research:
  Male NU/J nude mice were given intraperitoneal injection with WZB117 (10 mg/kg) daily for 10 weeks.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WZB-117, WZB 117, WZB117, inhibit, GLUT1, GLUT, Glucose transporter, Inhibitor

Compound Identifiers

PubChem CID

46830365