WZ811

SKU: orb1307568

Description

WZ811 is a potent and selective small molecule antagonist of the CXCR4 receptor, exhibiting an EC50 of 0.3 nM. It is a valuable research tool for studying CXCR4's role in cancer metastasis, stem cell mobilization, and inflammatory diseases in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 55778-02-4
• MW: 290.36
• Purity: 99.93% (May vary between batches)
• Formula: C₁₈H₁₈N₄
• SMILES: C(Nc1ccccn1)c1ccc(CNc2ccccn2)cc1
• Target: CXCR
• Solubility: DMSO:28 mg/mL (96.43 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  CXCR4:0.3 nM(EC50)
• In Vivo:
  WZ811 markedly inhibits the reduction of cAMP caused by SDF-1. It also demonstrates inhibitory effects on SDF-1-mediated invasion with an EC50 value of 5.2 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXC chemokine receptors, CXCR, CXCR4, inhibit, Inhibitor, WZ811, WZ-811, WZ 811

Compound Identifiers

PubChem CID

11565518