WZ3146

SKU: orb1223387

Description

WZ-3146 is a covalent or irreversible pyrimidine-based EGFR inhibitor against EGFR T790M. WZ-3146 was identified by screening an irreversible kinase inhibitor library specifically against EGFR T790M. WZ-3146 potently suppresses the growth of EGFR-T790M-containing cell lines and inhibits EGFR phosphorylation. WZ-3146 is also effective in murine models of lung cancer driven by EGFR T790M. WZ-3146 may be clinically more effective and better tolerated than quinazoline-based inhibitors. All current EGFR inhibitors possess a structurally related quinazoline-based core scaffold and were identified as ATP-competitive inhibitors of wild-type EGFR.

Key Properties

• CAS Number: 1214265-56-1
• MW: 464.95
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₅ClN₆O₂
• SMILES: CN1CCN(CC1)C1=CC=C(NC2=NC=C(Cl)C(OC3=CC(NC(=O)C=C)=CC=C3)=N2)C=C1
• Target: EGFR (E746_A750)| EGFR (E746_A750/T790M)| EGFR (L858R)| EGFR (L858R/T790M)
• Solubility: DMSO : 150 mg/mL. 322.62 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WZ3146 | WZ-3146 | WZ 3146

Quick Database Links

Gene Symbol

EGFR (E746_A750)| EGFR (E746_A750/T790M)| EGFR (L858R)| EGFR (L858R/T790M)