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WYE-125132

SKU: orb1226918

Description

A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM; dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases; inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis; shows potent single-agent antitumor activity against multiple cancer models.

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Key Properties

CAS Number1144068-46-1
MW519.5954
Purity>98% (HPLC)
FormulaC27H33N7O4
SMILESO=C(NC)NC1=CC=C(C2=NC(N3CC(O4)CCC4C3)=C5C(N(C(CC6)CCC76OCCO7)N=C5)=N2)C=C1
TargetmTOR
SolubilityDMSO: ≥ 62 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

WYE-132 | WYE125132

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  • WYE-132 [orb1686583]

    99.16%

    1144068-46-1

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    C27H33N7O4

    1 mg, 5 mg, 10 mg, 25 mg, 100 mg, 1 ml x 10 mM (in DMSO), 50 mg
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Protocol Information

WYE-125132 (orb1226918)

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100 mg
200 mg
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10 mg
$ 380.00
50 mg
$ 1,230.00