WWQ-03-012

SKU: orb3174126

Description

WWQ-03-012 is a selective inhibitor of deSUMOylating isopeptidase DESI2, with an IC50 of 47.3 μM. It induces ubiquitination-proteasome degradation of JAK2-V617F without significantly affecting wild-type JAK2. This compound can disrupt the JAK2-STAT3/5 signaling pathway, inhibit cell proliferation, and induce apoptosis. When used in combination with Ruxolitinib, WWQ-03-012 demonstrates a synergistic effect, enhancing cytotoxicity against JAK2 mutant cells. It is applicable in cancer research, specifically in studying myeloproliferative neoplasms.

Key Properties

• CAS Number: 3076807-15-0
• MW: 392.43
• Formula: C₂₀H₁₆N₄O₃S
• SMILES: N(C(=O)[C@@H]1CN(C#N)CC1)C2=NC=3C(S2)=CC=C(C3)C=4C=C5C(=CC4)OCO5
• Target: DUB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DUB