Wu-5

SKU: orb2900433

Description

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

Key Properties

• CAS Number: 2630378-05-9
• MW: 351.33
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃NO₇S
• SMILES: O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC
• Target: DUB
• Solubility: In Vitro: DMSO : 25 mg/mL (71.16 mM; Ultrasonic (<60°C)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: U937, HL60, MV4-11, Molm13, and MV4-11-R cells. Concentration: 10 μM. Incubation time: 24, 48, 72 h. Result: Significantly inhibited the growth of the FLT3-ITD-positive cells (MV4-11, MV4-11-R and Molm13 cells), but had no or little effect on the proliferation of the FLT3-ITD negative cells (U937 and HL60 cells). Apoptosis Analysis Cell line: MV4-11, and Molm13 cells. Concentration: 1, 2.5, 5 μM Incubation time: 24, 48 h. Result: Induced the apoptosis of MV4-11 and Molm13 in a concentration and time-dependent manner. Western blot analysis. Cell line: MV4-11, MV4-11-R, and Molm13 cells. Concentration: 5 μM. Incubation time: 24 h. Result: Induced FLT3-ITD degradation.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DUB