WS-11

SKU: orb2695425

Description

WS-11 is a potent, reversible non-covalent inhibitor of both wild-type (IC50=3.9 nM) and C481S mutant (IC50=2.2 nM) BTK, stabilized by key hydrogen bonds and π-interactions with residues PHE540 and LYS430. It is a valuable chemical probe for studying B-cell signaling pathways in both cellular and animal models of autoimmune diseases and B-cell malignancies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2759280-09-4
• MW: 511.51
• Formula: C₂₆H₂₂FN₉O₂
• SMILES: O=C1N=C(C=C1)N2CCCC(N3N=C(C=4C=CC(=CC4F)C(=O)NC5=NC=CC=C5)C=6C(=NC=NC63)N)C2
• Target: BTK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652643