WRN inhibitor 18

SKU: orb2814300

Description

WRN inhibitor 18 (compound 306) is a small molecule, orally bioavailable inhibitor of the Werner syndrome helicase (WRN). It is a research tool for investigating DNA damage response and synthetic lethality in microsatellite unstable (MSI) cancers, demonstrating antitumor efficacy in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Key Properties

• CAS Number: 3064599-42-1
• MW: 751.74
• Formula: C₃₅H₃₅F₆N₅O₅S
• SMILES: C(O)(=O)[C@@H]1[C@H](C[C@H](C[C@H]1C(NC2=C(F)C=C(C(F)(F)F)C=C2)=O)N3CCC(F)(F)C3)C4=CC=C(N(S(=O)(=O)C=5C=C6C(=CC5)N(C)C(C)=N6)C)C=C4
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172618048