WRN inhibitor 11

SKU: orb2695289

Description

WRN inhibitor 11 (Example 17) is a potent, orally bioavailable small molecule targeting the WRN helicase, exhibiting an IC50 of 63 nM. This inhibitor is a valuable research tool for studying DNA repair mechanisms in microsatellite unstable (MSI) cancer models, both in cellular and animal studies.

Research Area

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Key Properties

• CAS Number: 3058317-61-3
• MW: 742.15
• Formula: C₃₄H₃₅ClF₃N₉O₅
• SMILES: O=C(C1=NC=NC(=C1O)C)N2CC3N(C=4C(=O)N5N=C(N=C5N(C4CC)CC(=O)NC6=CC(Cl)=C(C=C6C)C(F)(F)F)C7=CCOCC7)C(C2)CC3
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652659