Wnt pathway inhibitor 3

SKU: orb1819100

Description

Wnt pathway inhibitor 3 is a potent and selective AC1 inhibitor (IC50 = 45 nM) with demonstrated antiproliferative effects. It has been utilized in both in vitro mechanistic studies and in vivo research, such as in mouse models of experimental osteoarthritis, to investigate potential therapeutic applications for ameliorating the disease.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology, Stem Cell & Developmental Biology; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 663213-98-7
• MW: 457.27
• Purity: 99.94% (May vary between batches)
• Formula: C₂₁H₁₇BrN₂O₅
• SMILES: C(#N)C=1C(C2=C(C=C3C(=C2)OCO3)OC1N)C4=CC(OC)=C(OCC=C)C(Br)=C4
• Target: Wnt/beta-catenin,Adenylate cyclase
• Solubility: DMSO:60 mg/mL (131.21 mM)

Bioactivity

• Target IC50:
  AC type I:45 nM
• In Vitro:
  Wnt pathway inhibitor 3 (compound 41) (0-100 μM; 72 h) exhibited anti-proliferative activity with IC50 values of 641, 470, 551, and 618 nM for HS68, Dld1, HCT116, and SW480 cells, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bcatenin, Adenylylcyclase, Adenylyl cyclase, adenylyl cyclase 1(AC1), betacatenin, beta-catenin, βcatenin, Wnt, Wnt/b-catenin, Wnt pathway inhibitor 3, Wnt/β-catenin, Wnt/betacatenin, Wntpathwayinhibitor3

Compound Identifiers

PubChem CID

3260543