WNK1-IN-1

SKU: orb1744291

Description

WNK1-IN-1 is a selective small molecule inhibitor of WNK1 kinase with an IC50 of 1.6 µM, effectively blocking downstream OSR1 phosphorylation. This tool compound is utilized in biochemical and cellular research to investigate pathways related to hypertension and cancer biology.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 324022-39-1
• MW: 446.14
• Purity: 98.09% (May vary between batches)
• Formula: C₁₃H₁₅BrCl₂N₂O₄S
• SMILES: [O-][N+](C1=CC(S(=O)(C(Br)(Cl)Cl)=O)=CC=C1NC2CCCCC2)=O
• Target: Serine Protease,Serine/threonin kinase
• Solubility: DMSO:80 mg/mL (179.32 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.4 mM)

Bioactivity

• In Vitro:
  WNK1-IN-1 (0.2-12.5 μM, 24 hours) treats endogenous OSR1 phosphorylated MDAMB231 breast cancer cells with an IC50 value of 4.3 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WNK1-IN1

Compound Identifiers

PubChem CID

15998580