WM-8014

SKU: orb1302918

Description

WM-8014 (MOZ-IN-3) is a potent and selective small molecule inhibitor of the histone acetyltransferase MOZ, exhibiting an IC50 of 55 nM. It is a valuable chemical probe for epigenetic research, enabling the study of MOZ function in both cellular and biochemical assays to investigate its role in transcription and development.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2055397-18-5
• MW: 384.42
• Purity: 99.95% (May vary between batches)
• Formula: C₂₀H₁₇FN₂O₃S
• SMILES: Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-c1ccccc1
• Target: Histone Acetyltransferase
• Solubility: DMSO:45 mg/mL (117.06 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.2 mM)

Bioactivity

• Target IC50:
  MOZ:55 nM
• In Vitro:
  MOZ-IN-3is an inhibitor of MOZ（IC50=55 nM）. MOZ-IN-3 causes cell senescence（IC50=1.6 μM） and suppresses the proliferation（IC50=551 nM）.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HATs, HAT, Histone Acetyltransferase, HistoneAcetyltransferase, Inhibitor, MOZ, MOZ-IN-3, inhibit, WM 8014, WM8014, WM-8014

Compound Identifiers

PubChem CID

133053564