WM-3835

SKU: orb1298369

Description

WM-3835 is a potent and selective small molecule inhibitor of KAT7 (MYST2/HBO1). It effectively inhibits osteosarcoma cell proliferation and migration while inducing apoptosis in vitro, making it a valuable chemical probe for epigenetic and cancer research.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2229025-70-9
• MW: 400.42
• Purity: 99.36% (May vary between batches)
• Formula: C₂₀H₁₇FN₂O₄S
• SMILES: Cc1cc(cc(C(=O)NNS(=O)(=O)c2cccc(O)c2)c1F)-c1ccccc1
• Target: Apoptosis,Histone Methyltransferase,Histone Acetyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.49 mM);DMSO:255 mg/mL (636.83 mM)

Bioactivity

• In Vitro:
  WM-3835, a novel and high-specific small molecule HBO1 inhibitor, was able to potently suppressed OS cell proliferation and migration, and led to apoptosis activation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H3K14ac, H4K12ac, Histone Acetyltransferase, HistoneAcetyltransferase, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, HATs, HAT, HBO1, KAT7, inhibit, MYST2, MYLK-HOXA9, invasion, Lysine Acetyltransferase 7, migration, OS) cell proliferation, osteosarcoma, acetyl-CoA, Apoptosis, apoptosis, WM 3835, WM3835, WM-3835, pOS-1

Compound Identifiers

PubChem CID

134581412