Windorphen

SKU: orb1299467

Description

Windorphen is a selective small molecule inhibitor of Wnt signaling. It is utilized in both in vitro and in vivo research to investigate pathways in oncology, stem cell biology, and developmental processes.

Research Area

Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 19881-70-0
• MW: 302.75
• Purity: 99.96% (May vary between batches)
• Formula: C₁₇H₁₅ClO₃
• SMILES: COc1ccc(cc1)C(\Cl)=C(\C=O)c1ccc(OC)cc1
• Target: Histone Acetyltransferase,Wnt/beta-catenin
• Solubility: DMSO:25 mg/mL (82.58 mM)

Bioactivity

• In Vivo:
  Windorphen that selectively blocks the Wnt signal required for ventral development. Windorphen exhibits remarkable specificity toward β-catenin-1 function, indicating that the two β-catenin isoforms found in zebrafish are not functionally redundant. Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with β-catenin. Finally, windorphen robustly and selectively kills cancer cells that harbor Wnt-activating mutations, supporting the therapeutic potential of this Wnt inhibitor class.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, βcatenin, Wnt/β-catenin, Windorphen, Wnt, Wnt/betacatenin, Wnt/b-catenin

Compound Identifiers

PubChem CID

735820