Wilforine

SKU: orb1300231

Description

Wilforine is a bioactive sesquiterpene pyridine alkaloid from Tripterygium wilfordii with demonstrated anti-fibrotic and anti-inflammatory properties, linked to the suppression of TNF-α, IL-6, and NO. Its bioactivity extends to insecticidal effects via Na+/K+-ATPase inhibition, supporting applications in pulmonary fibrosis research and neuropharmacological studies both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 11088-09-8
• MW: 867.85
• Purity: 98.40% (May vary between batches)
• Formula: C₄₃H₄₉NO₁₈
• SMILES: CC(OC[C@]12[C@@]34[C@@H]([C@]([C@H]([C@H]2OC(C)=O)OC(C)=O)([H])[C@@](O3)(COC(C5=CC=CN=C5CC[C@@H](C(O[C@]([C@@H]([C@@H]1OC(C)=O)OC(C6=CC=CC=C6)=O)([H])[C@@]4(O)C)=O)C)=O)C)OC(C)=O)=O
• Target: ATPase
• Solubility: DMSO:50 mg/mL (57.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.3 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Na+/K+-ATPase, inhibit, Inhibitor, Wilforine

Compound Identifiers

PubChem CID

601100