WH244

SKU: orb2564594

Description

WH244 is a potent and selective PROTAC degrader of BCL-2 and BCL-xL, with DC50 values of 7.4 nM and 0.6 nM, respectively. It induces target ubiquitination and proteasomal degradation, restoring apoptosis and demonstrating antitumor efficacy in cellular and in vivo cancer research models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2941088-96-4
• MW: 1681.51
• Formula: C₈₃H₁₀₅ClF₃N₁₃O₁₁S₄
• SMILES: C(C1=C(CC[C@](CN2CCN(C(CN3CCN(CC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)CC3)=O)CC2)(C)C1)C7=CC=C(Cl)C=C7)N8CCN(CC8)C9=CC=C(C(NS(=O)(=O)C%10=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN%11[C@@]%12(C[C@](C%11)(OC%12)[H])[H])CSC%13=CC=CC=C%13)C=C%10)=O)C=C9
• Target: Apoptosis,PROTACs,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169938320