Werner syndrome RecQ helicase-IN-2

SKU: orb1745125

Description

Werner syndrome RecQ helicase-IN-2 is a potent and selective small molecule inhibitor of the WRN helicase. It is a valuable chemical probe for investigating WRN's role in DNA repair and genome stability, facilitating research into microsatellite-unstable cancers such as colorectal and gastric carcinomas in cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2869954-51-6
• MW: 681.67
• Purity: 99.02% (May vary between batches)
• Formula: C₃₂H₃₄F₃N₉O₅
• SMILES: O=C(C1=NC=NC(=C1O)C)N2CCN(C=3C(=O)N4N=C(N=C4N(C3CC)CC(=O)NC5=CC=C(C=C5C)C(F)(F)F)C6=CCOCC6)CC2
• Target: DNA/RNA Synthesis
• Solubility: DMSO:30 mg/mL (44.01 mM)

Bioactivity

• Target IC50:
  WRN:100 nM
• In Vitro:
  Werner syndrome RecQ helicase-IN-2 is an inhibitor of RecQ DNA helicase (WRN) with an IC50 value of 100 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166140819