Werner syndrome RecQ helicase-IN-3

SKU: orb1745124

Description

Werner syndrome RecQ helicase-IN-3 is a potent, orally bioavailable small molecule inhibitor of the WRN helicase, demonstrating anticancer and antiproliferative effects with an IC50 of 0.06 µM. It serves as a valuable chemical probe for researching DNA damage response and synthetic lethality in microsatellite unstable cancers, applicable in both cellular and animal model studies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2869954-98-1
• MW: 687.07
• Purity: 99.60% (May vary between batches)
• Formula: C₃₁H₃₀ClF₃N₈O₅
• SMILES: O=C(C1=NC=CC=C1O)N2CCN(C=3C(=O)N4N=C(N=C4N(C3CC)CC(=O)NC5=CC=C(C=C5Cl)C(F)(F)F)C6=CCOCC6)CC2
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166140846