WEE1-IN-14

SKU: orb3173345

Description

WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor, with an IC50 of 0.5 nM determined by L-RB-FEP calculations and 1.0 nM in ADP-Glo​​ kinase assays. Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removing cell cycle regulation, leading to premature mitotic failure and subsequent tumor cell apoptosis. Thus, WEE1-IN-14 serves as a valuable tool for studying cancer biology.

Research Area

Cell Biology

Key Properties

• CAS Number: 2803921-87-9
• MW: 510.42
• Formula: C₂₅H₂₅Cl₂N₇O
• SMILES: O=C1C2=CNC3=NC(=CC3=C2N(C)CN1C=4C(Cl)=CC=CC4Cl)C=5C=NN(C5)C6CCN(C)CC6
• Target: Wee1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Wee1