WCF-598

SKU: orb3211295

Description

WCF-598 is a RXRγ degrader (Kd: 234.2 nM) and an AR-V7 PROTAC degrader. It induces RXRγ degradation through the ubiquitin-proteasome pathway and can bind directly to RXRγ. Additionally, WCF-598 indirectly induces AR-V7 degradation by destabilizing the RXRγ-AR-V7 complex, reducing AR-V7 levels, and inhibiting the transcription of AR-V7 downstream target genes. It promotes tumor cell apoptosis, inhibits cell proliferation, activates the p53 signaling pathway, and impedes cell cycle progression. WCF-598 is applicable in prostate cancer research.

Key Properties

• CAS Number: 3059574-58-9
• MW: 894.11
• Formula: C₅₄H₆₃N₅O₇
• SMILES: O=C(O)C=1C=CC(=CC1)C2=NC3=CC(=CC=C3N(C=4C=C5C(=CC24)C(C)(C)CCC5(C)C)C)NC(=O)CCCCCCCCCCCOC6=CC=CC=7C(=O)N(CC67)C8C(=O)NC(=O)CC8
• Target: Retinoid Receptor,Androgen Receptor,PROTACs,MDM-2/p53,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Retinoid Receptor,Androgen Receptor,PROTACs,MDM-2/p53,Apoptosis,Caspase