WB214

SKU: orb2815550

Description

WB214 is a potent molecular glue degrader of MDM2 (IC50 = 1.2 nM) and GSPT1, inducing p53 degradation. It demonstrates strong antiproliferative activity in leukemia cell lines, making it a valuable chemical probe for targeted protein degradation research in oncology.

Key Properties

• CAS Number: 2640723-72-2
• MW: 846.29
• Formula: C₄₄H₄₃ClF₃N₅O₇
• SMILES: O=C(OCC)C=1NC=2C=C(Cl)C=CC2C1C(C(=O)NC(C)(C)C)N(C(=O)CCCCC#CC3=CC=CC=4C(=O)N(CC34)C5C(=O)NC(=O)CC5)CC6=CC(F)=C(F)C(F)=C6

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164627691