VY-3-135

SKU: orb1297911

Description

VY-3-135 is a potent and selective oral ACSS2 inhibitor (IC50 = 44 nM) with no activity against ACSS1/ACSS3. It effectively blocks ACSS2-dependent fatty acid metabolism in vitro and in vivo, making it a valuable tool for researching cancer metabolism and metabolic disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1824637-41-3
• MW: 429.51
• Purity: 98.00% (May vary between batches)
• Formula: C₂₆H₂₇N₃O₃
• SMILES: CCn1c(nc2ccc(cc12)C(=O)NC[C@@H](C)O)C(O)(c1ccccc1)c1ccccc1
• Target: Acetyl-CoA Carboxylase,Others,Fatty Acid Synthase
• Solubility: DMSO:46.67 mg/mL (108.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM)

Bioactivity

• In Vivo:
  METHODS: BT474-transplanted mice were randomly assigned and treated with VY-3-135 (100 mg/kg) by intraperitoneal (IP) injection or oral gavage. Tumor size was measured in mice. RESULTS VY-3-135 inhibited the growth of MDA-MB-468 (ACSS2 high) tumors but had no effect on WHIM12 (ACSS2 low) tumors.
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• In Vitro:
  METHODS: BT474 cells were treated with VY-3-135 (0.01, 0.1, 1 μM), and SKBr3 cells were treated with VY-3-135 (1 μM). RESULTS VY-3-135 completely blocked fatty acid synthesis from acetate in SKBr3 cells. VY-3-135 is an effective targeted ACSS2 inhibitor in cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast cancer, ACSS2, Inhibitor, FattyAcidSynthase, Fatty Acid Synthase, inhibit, orally active, stable ACSS2 inhibitor, VY3135, VY-3-135, VY 3 135

Compound Identifiers

PubChem CID

92131155