VX-745

SKU: orb1225702

Description

A potent and selective p38α kinase inhibitor with IC50 of 9 nM; shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6); exhibits inhibition of PBMC IL-1β and TNFα IC50 of 45 and 51 nM, respectively; possesses favorable PK profile, and demonstrates good in vivo activity in models of inflammation.Alzheimer's Disease Phase 2 Clinical.

Key Properties

• CAS Number: 209410-46-8
• MW: 436.2621
• Purity: >98% (HPLC)
• Formula: C₁₉H₉Cl₂F₂N₃OS
• SMILES: O=C1C(C2=C(Cl)C=CC=C2Cl)=C3C=CC(SC4=CC=C(F)C=C4F)=NN3C=N1
• Target: p38 MAPK
• Solubility: DMSO: 13.08 mg/mL (Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VX 745 | VX745 | Neflamapimod

Quick Database Links

Gene Symbol

p38 MAPK