VVD-849

SKU: orb3136596

Description

VVD-849 is a RAS ligand that covalently binds to cysteine at position 242 within the RAS binding domain of PI3Kp110α, enhancing RAS/PI3K interaction. It partially inhibits pAKT(S473) in tumors overexpressing HER2. VVD-849 is applicable in cancer research, including studies on breast cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3055321-14-4
• MW: 636.15
• Formula: C₂₉H₃₁ClFN₃O₆S₂
• SMILES: S(=O)(=O)(C1=C(C=C(Cl)C=C1)C2=CC(OCC3=CC=CC=N3)=CC=C2)N4CCC(C(N[C@H](/C=C\S(C)(=O)=O)C)=O)(F)CC4
• Target: PI3K,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,Ras