VVD-699

SKU: orb3028411

Description

VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3055319-82-6
• MW: 573.097
• Formula: C₂₅H₃₀ClFN₂O₆S₂
• SMILES: S(=O)(=O)(C1=C(C=C(OC)C=C1)C2=C(Cl)C=CC=C2)N3[C@H](C)C[C@@](C(N[C@@H](/C=C\S(C)(=O)=O)C)=O)(F)CC3
• Target: PI3K,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,Ras