VUF10460

SKU: orb1303508

Description

VUF10460 is a selective, non-imidazole agonist for the histamine H4 receptor. It is a valuable research tool for investigating the role of this receptor in immunological and inflammatory processes, applicable in both in vitro binding assays and in vivo models of disease.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1028327-66-3
• MW: 269.34
• Purity: 99.57% (May vary between batches)
• Formula: C₁₅H₁₉N₅
• SMILES: CN1CCN(CC1)c1cc(nc(N)n1)-c1ccccc1
• Target: Histamine Receptor
• Solubility: DMSO:45 mg/mL (167.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.43 mM)

Bioactivity

• Target IC50:
  H4 receptor:7.46(pKi)
• In Vivo:
  HCl-induced rat gastric lesions are significantly enhanced by the H4 receptor agonist VUF10460, an effect not altered by the H4 receptor antagonist JNJ7777120. VUF10460 exhibits approximately 50-fold selectivity for the rat H(4) receptor over the H(3) receptor.
• In Vitro:
  UF10460 exhibits binding affinities to rat H3 and H4 receptors with pKi values of 5.75 and 7.46, respectively, whereas VUF10460 demonstrates approximately 50-fold selectivity for the rat H4 receptor over the H3 receptor .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VUF 10460, VUF10460, VUF-10460, Histamine Receptor, HistamineReceptor, Inhibitor, H4 receptor, inhibit

Compound Identifiers

PubChem CID

25129523