VU10010

SKU: orb1940364

Description

VU 10010 is allosteric potentiator of M4 acetylcholine receptors.

Key Properties

• CAS Number: 633283-39-3
• MW: 345.85
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₆ClN₃OS
• SMILES: Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc(Cl)cc1
• Target: AChR
• Solubility: In Vitro: DMSO : 125 mg/mL (361.43 mM)

Bioactivity

• In Vitro:
  VU10010 potentiates the M4 response to acetylcholine 47-fold while having no activity at other mAChR subtypes (rM1, rM2, rM3 or rM5). VU10010 causes an increase in affinity for ACh and M4-mediated [35S]GTPγS binding. VU10010 (10 μM) has no agonist, antagonist or allosteric potentiator activity at P2Y1R or mGluR5. The EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VU 10010

Quick Database Links

Gene Symbol

AChR