VU0155056

SKU: orb1738076

Description

VU0155056 is a potent dual inhibitor of phospholipase D isoforms PLD1 (IC50 = 81 nM) and PLD2 (IC50 = 240 nM) in vitro, with cellular activity below 1 µM. It is a valuable research tool for studying PLD signaling in cancer biology, specifically for investigating mechanisms of breast cancer cell invasion and metastasis.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1130067-18-3
• MW: 414.5
• Purity: 99.15% (May vary between batches)
• Formula: C₂₅H₂₆N₄O₂
• SMILES: O=C(NCCN1CCC(N2C(=O)NC=3C=CC=CC32)CC1)C=4C=CC=5C=CC=CC5C4
• Target: Phospholipase

Bioactivity

• In Vitro:
  VU0155056 was tested in HEK293, PC12, and human neutrophil models at concentrations ranging from 0.5 to 20 μM for 10 minutes to 24 hours. VU0155056 significantly reduced levels of phosphatidic acid (PA) and phosphatidylbutanol (PBut), indicating effective inhibition of PLD1 and PLD2 activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SA2572, SA-2572, VU 0155056, VU0155056, VU-0155056

Compound Identifiers

PubChem CID

25105704