VU0119498

SKU: orb1299108

Description

VU0119498 is a selective M1 muscarinic receptor agonist (EC50 = 3.1 μM) and a positive allosteric modulator for M3 and M5 receptors. It exhibits neuroprotective properties and is utilized in research exploring cholinergic signaling, cognitive function, and neurodegenerative disease models in both cellular and animal studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 79183-37-2
• MW: 316.15
• Purity: 100.00%
• Formula: C₁₅H₁₀BrNO₂
• SMILES: Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
• Target: AChR
• Solubility: DMSO:15 mg/mL (47.45 mM)

Bioactivity

• Target IC50:
  M1:3.1 μM(EC50)
• In Vivo:
  VU0119498 treatment of wild-type mice caused a significant increase in plasma insulin levels, accompanied by a striking improvement in glucose tolerance

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VU0119498, VU-0119498, VU 0119498, inhibit, Muscarinic acetylcholine receptor, pan, mAChR, Inhibitor, antidiabetic

Compound Identifiers

PubChem CID

3008304