VU 0365114

SKU: orb1308943

Description

VU 0365114 is a selective positive allosteric modulator of the muscarinic acetylcholine receptor M5 (CHRM5), potentiating acetylcholine-induced calcium mobilization with an EC50 of 2.7 µM. This small molecule is a valuable research tool for investigating M5 receptor function in neuropharmacology, utilized in both in vitro signaling assays and in vivo studies of central nervous system pathways.

Research Area

Neuroscience

Key Properties

• CAS Number: 1208222-39-2
• MW: 397.35
• Purity: 99.86% (May vary between batches)
• Formula: C₂₂H₁₄F₃NO₃
• SMILES: FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
• Target: AChR
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:45 mg/mL (113.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.03 mM)

Bioactivity

• Target IC50:
  M5 mAChR:2.7 μM(EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

M5 mAChR, mAChR, mAChR M5, inhibit, Muscarinic acetylcholine receptor, Inhibitor, VU 0365114, VU0365114, VU-0365114

Compound Identifiers

PubChem CID

45281794