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VS-5584

SKU: orb1223369

Description

VS-5584, also known as SB2343, is a potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.

Images & Validation

Key Properties

CAS Number1246560-33-7
MW354.41
Purity>98% (HPLC)
FormulaC17H22N8O
SMILESCC(C)n1c(C)nc2c1nc(nc2c1cnc(N)nc1)N1CCOCC1
TargetAmino Acids and Derivatives
SolubilityDMSO : 33.33 mg/mL. 94.04 mM;

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VS5584 | VS 5584 | VS5584 | SB2343

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Protocol Information

VS-5584 (orb1223369)

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Available Sizes

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200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 160.00
25 mg
$ 260.00
50 mg
$ 450.00
100 mg
$ 710.00