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VRT-043198

SKU: orb1739848

Description

VRT-043198 is the active metabolite of VX-765 (Belnacasan) and a potent, BBB-permeable inhibitor of ICE/caspase-1 (Ki=0.8 nM) and caspase-4 (Ki=0.6 nM). It is widely used in research to investigate inflammasome biology and related pathologies in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number244133-31-1
MW480.94
FormulaC22H29ClN4O6
SMILESCC(C)(C)[C@H](NC(=O)c1ccc(N)c(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C=O
TargetOthers,Drug Metabolite,Caspase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

VRT-043198 (orb1739848)

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