VPC-70063

SKU: orb1301220

Description

VPC-70063 is a small molecule inhibitor of the c-Myc/MAX transcription factor complex, demonstrating potent inhibition of Myc-driven transcriptional activity and downstream pathways. This compound is a valuable chemical probe for anticancer research, enabling the study of Myc biology in both cellular and biochemical assays.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 13571-44-3
• MW: 378.34
• Purity: 99.98% (May vary between batches)
• Formula: C₁₆H₁₂F₆N₂S
• SMILES: N(C(NCC1=CC=CC=C1)=S)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
• Target: Apoptosis,c-Myc,PARP
• Solubility: DMSO:45 mg/mL (118.94 mM)

Bioactivity

• In Vitro:
  VPC-70063 (6.25, 12.5, and 25 μM) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM) disrupts the interaction of Myc-Max with DNA in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-, poly ADP ribose polymerase, VPC70063, VPC-70063, VPC 70063, UBE2C, Myc, Myc-Max, inhibit, LNCaP, PARP, Inhibitor, c-Myc, c-Myc-MAX, cMyc, Apoptosis, Anticancer, AR-V7

Compound Identifiers

PubChem CID

4142933