VP3.15 dihydrobromide

SKU: orb1301384

Description

VP3.15 dihydrobromide is an orally active, brain-penetrant small molecule that potently inhibits both PDE7 and GSK-3 enzymes, with respective IC50 values of 1.59 µM and 0.88 µM. This dual inhibitor is a valuable research tool for investigating neurodegenerative and psychiatric disorders in both cellular and animal models.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1281681-33-1
• MW: 528.3
• Purity: 99.67% (May vary between batches)
• Formula: C₂₀H₂₄Br₂N₄OS
• SMILES: Br.Br.C(CN1CCOCC1)\N=c1\nc(-c2ccccc2)n(s1)-c1ccccc1
• Target: GSK-3,PDE
• Solubility: DMSO:22.5 mg/mL (42.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.79 mM)

Bioactivity

• Target IC50:
  PDE7:1.59 μM|GSK-3:0.88 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3, GSK3, Inhibitor, inhibit, Phosphodiesterase (PDE), phosphodiesterase, PDE7, VP3.15, VP3.15 dihydrobromide, VP3.15 Dihydrobromide, VP-3.15 dihydrobromide

Compound Identifiers

PubChem CID

57326492