Vosilasarm

SKU: orb2276858

Description

RAD140 is a selective androgen receptor modulator (SARM) under investigation for its potential therapeutic applications. Preclinical research in vitro and in vivo explores its utility in addressing muscle atrophy and hormone-sensitive cancers, such as breast cancer.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1182367-47-0
• MW: 393.82
• Purity: 99.60%
• Formula: C₂₀H₁₆ClN₅O₂
• SMILES: [H][C@@](C)(O)[C@@]([H])(Nc1ccc(C#N)c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N
• Target: Androgen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.08 mM);DMSO:10 mM

Bioactivity

• Target IC50:
  Androgen receptor:7 nM
• In Vivo:
  in vivo: The stability of RAD140 is high (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes, and it also had good bioavailability in rats and monkeys. RAD140 is also neuroprotective using the rat kainate lesion model. RAD140 is shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate.
• In Vitro:
  RAD140 demonstrates excellent affinity for the androgen receptor (Ki = 7 nM) as well as good selectivity over other steroid hormone nuclear receptors.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AndrogenReceptor, Androgen Receptor, androgen, neuronal, neuroprotective, oral, inhibit, Inhibitor, RAD 140, RAD140, RAD-140, Testolone, Vosilasarm

Compound Identifiers

PubChem CID

44200882