Voriconazole

SKU: orb1310918

Description

Voriconazole (UK-109496) is a triazole antifungal compound that acts as a potent inhibitor of fungal sterol 14-alpha-demethylase and the mammalian cytochrome P-450 CYP3A enzyme. It is widely used in research for studying antifungal mechanisms, drug interactions, and in both in vitro susceptibility testing and in vivo infection models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 137234-62-9
• MW: 349.31
• Purity: 99.91% (May vary between batches)
• Formula: C₁₆H₁₄F₃N₅O
• SMILES: CC(C1=NC=NC=C1F)C(O)(CN1C=NC=N1)C1=CC=C(F)C=C1F
• Target: Antibacterial,Antifection,Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.31 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:247 mg/mL (707.11 mM);Ethanol:16 mg/mL (45.8 mM)

Bioactivity

• In Vivo:
  In vitro, Voriconazole exhibits greater or comparable antifungal activity against most tested molds than Itraconazole and Amphotericin B. Voriconazole effectively inhibits certain conditioned filamentous fungi and dimorphic fungi (molds), as well as yeast species. At concentrations of ≤1 μg/mL, Voriconazole can inhibit 95% of fungal strains.
• In Vitro:
  Intraperitoneal administration of 5 mg/kg Voriconazole combined with 1.25 mg/kg Amphotericin B significantly reduces fungal counts in selected tissues of guinea pigs when compared to control groups. Furthermore, Voriconazole at 5 mg/kg, when combined with any dose of Caspofungin Acetate, decreases tissue fungal loads, specifically demonstrating a significant reduction in the number of positive cultures. In immunocompromised guinea pigs with pulmonary aspergillosis, Voriconazole effectively reduces pulmonary Aspergillus spp. counts, displaying superior results to those observed with Itraconazole.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

14-α Demethylase, blastomycosis, broad-spectrum, antifungal, murine, inhibit, Inhibitor, Fungal, pulmonary, UK 109496, UK109496, UK-109496, Voriconazole, triazole

Compound Identifiers

PubChem CID

5231054