Vorapaxar sulfate

SKU: orb1304543

Description

Vorapaxar sulfate, marketed as Zontivity, is a potent oral antagonist of the protease-activated receptor-1 (PAR-1). It is utilized in research to investigate antiplatelet mechanisms and has been studied in both in vitro assays and in vivo models of thrombosis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 705260-08-8
• MW: 590.66
• Purity: 99.99%
• Formula: C₂₉H₃₅FN₂O₈S
• SMILES: OS(O)(=O)=O.[H][C@@]12C[C@]3([H])C[C@@H](CC[C@@]3([H])[C@H](\C=C\c3ccc(cn3)-c3cccc(F)c3)[C@]1([H])[C@@H](C)OC2=O)NC(=O)OCC
• Target: Protease-activated Receptor
• Solubility: DMSO:70 mg/mL (118.51 mM)

Bioactivity

• Target IC50:
  PAR1:8.1 nM (Ki)

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Zontivity, Vorapaxar, vorapaxar, vorapaxar monosulfate, vorapaxar Monosulfate, Vorapaxar sulfate, Vorapaxar Sulfate, SCH 530348, SCH 530348 Sulfate, SCH 530348 sulfate, SCH530348, SCH-530348, SCH530348 Sulfate, SCH-530348 Sulfate, Protease Activated Receptor (PAR), Protease-Activated Receptor (PAR), Proteaseactivated Receptor, ProteaseactivatedReceptor, Thrombin receptors, Inhibitor, inhibit, PAR-1

Compound Identifiers

PubChem CID

10077129