Vonafexor

SKU: orb1220251

Description

Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.(In Vitro):Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).

Key Properties

• CAS Number: 1192171-69-9
• MW: 489.76
• Purity: >98% (HPLC)
• Formula: C??H??Cl?N?O?S
• SMILES: O=C(C1=CC2=C(Cl)C(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=CC=C2O1)O
• Target: FXR
• Solubility: DMSO : 83.33 mg/mL (170.14 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EYP001

Quick Database Links

Gene Symbol

FXR