Volasertib trihydrochloride

SKU: orb1690124

Description

Volasertib trihydrochloride is a potent, orally active ATP-competitive inhibitor of PLK1, PLK2, and PLK3, inducing mitotic arrest and apoptosis. It demonstrates significant antitumor efficacy in both in vitro cellular assays and in vivo xenograft models across various cancer types, supporting its role in oncology research.

Research Area

Cell Biology

Key Properties

• CAS Number: 946161-17-7
• MW: 728.2
• Formula: C₃₄H₅₃Cl₃N₈O₃
• SMILES: Cl.Cl.Cl.CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O |wU:28.29,5.1,wD:25.22,(16.69,,;,-12.23,;4.18,-12.23,;-12.27,2.97,;-10.94,3.74,;-9.6,2.97,;-8.27,3.74,;-8.27,5.28,;-9.6,6.05,;-6.94,6.05,;-6.94,2.97,;-5.6,3.74,;-4.27,2.97,;-2.93,3.74,;-1.6,2.97,;-1.6,1.43,;-.27,.66,;1.07,1.43,;1.07,2.97,;-.27,3.74,;-.27,5.28,;1.07,6.05,;2.4,.66,;3.73,1.43,;2.4,-.88,;3.73,-1.65,;3.73,-3.19,;5.07,-3.96,;6.4,-3.19,;6.4,-1.65,;5.07,-.88,;7.74,-3.96,;9.07,-3.19,;10.4,-3.96,;10.4,-5.5,;11.74,-6.27,;11.74,-7.81,;12.51,-9.15,;10.97,-9.15,;9.07,-6.27,;7.74,-5.5,;-4.27,1.43,;-5.6,.66,;-6.94,1.43,;-8.27,.66,;-8.27,-.88,;-9.6,1.43,;-10.94,.66,)|
• Target: Others,PLK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16718566