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Vodobatinib

SKU: orb1218865

Description

Vodobatinib is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.

Images & Validation

Key Properties

CAS Number1388803-90-4
MW453.92
Purity>98% (HPLC)
FormulaC27H20ClN3O2
SMILESCC1=C(C(=CC=C1)Cl)C(=O)NNC(=O)C2=CC(=C(C=C2)C)C#CC3=CC4=CC=CC=C4N=C3
TargetBcr-Abl
SolubilityDMSO:10 mM

Bioactivity

In Vitro
In Ba/F3 cells expressing BCR-ABL1, BCR-ABL1L248V, BCR-ABL1Y253H, or BCR-ABL1E255V, Vodobatinib (K0706; 0-2000 nM) treatment shows potent inhibition of BCR-ABL1 tyrosine autophosphorylation.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

K-0706

Similar Products

  • Vodobatinib [orb1298554]

    99.93% (May vary between batches)

    1388803-90-4

    453.92

    C27H20ClN3O2

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 500 mg
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Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 210.00
25 mg
$ 370.00
50 mg
$ 590.00
100 mg
$ 870.00