Voacamine

SKU: orb1304707

Description

Voacamine (Voacanginine) is an indole alkaloid with dual activity as a cannabinoid CB1 receptor antagonist and a P-glycoprotein (P-gp) inhibitor. Its potential rhythmic effects and ability to overcome multidrug resistance in tumor cells make it a compound of interest for neuropharmacology and oncology research, applicable in both in vitro and in vivo experimental models.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3371-85-5
• MW: 704.9
• Purity: 99.97% (May vary between batches)
• Formula: C₄₃H₅₂N₄O₅
• SMILES: CC[C@H]1C[C@H]2CN3CCc4c([nH]c5cc([C@H]6C[C@@H]7C([C@@H](Cc8c6[nH]c6ccccc86)N(C)C\C7=C\C)C(=O)OC)c(OC)cc45)[C@](C2)([C@H]13)C(=O)OC
• Target: Akt,mTOR,EGFR,Apoptosis,P-gp,PI3K,Autophagy,Cannabinoid Receptor
• Solubility: DMSO:7.05 mg/mL (10 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.42 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Multidrug resistance protein 1, obesity, metabolic, MDR1, alkaloid, ABCB1, cannabinoid, Cannabinoid Receptor, CannabinoidReceptor, antagonistic, Cluster of differentiation 243, CD243, CB, CB1, syndrome, P-glycoprotein, Pgp, P-gp, P-gp (P-glycoprotein), receptor, Voacamine, Voacanginine

Compound Identifiers

PubChem CID

155859183