VLX1570

SKU: orb1303205

Description

VLX1570 is a potent competitive inhibitor of proteasome-associated deubiquitinase (DUB) activity, exhibiting IC50 values between 4.2 and 8.6 µM, with particular potency against USP14. This small molecule is a valuable research tool for studying proteasome function, protein degradation pathways, and cellular homeostasis in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1431280-51-1
• MW: 469.39
• Purity: 99.91% (May vary between batches)
• Formula: C₂₃H₁₇F₂N₃O₆
• SMILES: [O-][N+](=O)c1cc(\C=C2\CCN(C\C(=C\c3ccc(F)c(c3)[N+]([O-])=O)C2=O)C(=O)C=C)ccc1F
• Target: DUB
• Solubility: DMSO:32 mg/mL (68.17 mM)

Bioactivity

• Target IC50:
  DUB:4.2-8.6 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Deubiquitinase, DUBs, DUB, VLX 1570, VLX1570, VLX-1570

Compound Identifiers

PubChem CID

118989091